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CHEMICAL NAME: (±)-Dimethyl-1-[1-(4-chlorophenyl) cyclobutyl]-N, N, 3-trimethylbutan-1-amine
HALF RELEASE: 1 hour
Sibutramin is a centrally acting inhibitor of reducing levels of serotonin and noradrenaline. It is structurally similar to amphetamines, although the mechanism of action is different.
Sibutramine reduces the uptake of serotonin (by 53%), norepinephrine (by 54%), and dopamine (by 16%), which increases the levels of these substances in the synaptic cleft, and help to increase the feeling of satiety, and thus affect the appetite. Older anorectic agents such as amphetamine and fenfluramine caused the more an increase of the release of these neurotransmitters, than the effect on the uptake. Although the mechanism of action is similar to that of tricyclic antidepressants, sibutramine has not shown antidepressant properties in the studies.
The use of sibutramine may cause kidney problems or digestive problems. It is a very dangerous product for people with heart problems, because it can lead to irregular heartbeat and high blood pressure, which in extreme cases can cause a heart attack.The most common side effects of sibutramine are headache, nausea, constipation or insomnia.
For the purposes of fat burning and weight reduction the maximum daily dose of sibutramine is 10-15 mg.